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Muscular Dystrophy / ALS News From Medical News Today
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Discovery Of Genes And Disease Mechanisms Behind Muscular Dystrophy Could Lead To A Biomarker-Based Diagnostic Test
Continuing a series of groundbreaking discoveries begun in 2010 about the genetic causes of the third most common form of inherited muscular dystrophy, an international team of researchers led by a scientist at Fred Hutchinson Cancer Research Center has identified the genes and proteins that damage muscle cells, as well as the mechanisms that can cause the disease...
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Enzyme Function Could Help Find Muscular Dystrophy Therapies
Study reveals function of glycosylating enzyme involved in muscular dystrophy, brain development and infection by arenaviruses such as Lassa fever; ability to assay enzyme activity could help screen potential muscular dystrophy therapies Researchers at the University of Iowa have worked out the exact function of an enzyme that is critical for normal muscle structure and is i...
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A Firmer Understanding Of Muscle Fibrosis In Duchenne Muscular Dystrophy
Researchers describe how increased production of a microRNA promotes progressive muscle deterioration in a mouse model of Duchenne muscular dystrophy (DMD), according to a study published online on January 2 in the Journal of Cell Biology*. As DMD patients age, their damaged muscle cells are gradually replaced by collagen-rich, fibrous tissue...
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Grafting Of Human Spinal Stem Cells Into ALS Rats Best With Immunosuppressant Combination
A team of researchers grafting human spinal stem cells into rats modeled with amyotrophic lateral sclerosis (ALS), also known as "Lou Gehrig's Disease," a degenerative, lethal, neuromuscular disease, have tested four different immunosuppressive protocols aimed at determining which regimen improved long-term therapeutic effects...
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Safety Of Customized Gene Therapy Demonstrated By Clinical Trial For Muscular Dystrophy
Researchers at the University of North Carolina at Chapel Hill have shown that it is safe to cut and paste together different viruses in an effort to create the ultimate vehicle for gene therapy. In a phase I clinical trial, the investigators found no side effects from using a "chimeric" virus to deliver replacement genes for an essential muscle protein in patients with muscular dystrophy...
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